A female medical investigator is developing a drug that can allow the possibility of an impotent female or male to procreate. But the true reason is that she is an hermaphrodite (dual sex) but her both sexual organs are impotent an unable to procreate. So she develops that drug, making two version, the blue one for males and the red for females. But as any new medicine she must try it out first, there is when her nurse assistants became useful and then she must analyse each reaction in each subject, including herself, expecting some interesting outcomes.

A female medical investigator is developing a drug that can allow the possibility of an impotent female or male to procreate. But the true reason is that she is an hermaphrodite (dual sex) but her both sexual organs are impotent an unable to procreate. So she develops that drug, making two version, the blue one for males and the red for females. But as any new medicine she must try it out first, there is when her nurse assistants became useful and then she must analyse each reaction in each subject, including herself, expecting some interesting outcomes.

This anime focuses on Kazama Mana, the main character of Yakin Byoutou 2. She works for a sanatorium as an intern nurse. Mana looks up to Nightingale, and she wants to be an angel in white like her. But Mizukawa Ayumu, the patient whose days are numbered, says to her that there is no angel and begins to make her the center of a sex game.

Haroumi Shiki, due to unforeseen events, is forced to stay at the home of three sisters with whom he used to play as a child. While there he grows closer to each of them in his own way.

Due to unavoidable circumstances, Haruomi is freeloading at his relatives’, the Orifushi sisters’, house. Since that day, his common everyday life has come to a screeching halt.

The eldest sister is the gentle and maternal Natsumi. The second is Akina, a bright and cheerful girl for whom a smile is well-suited. The youngest sister is the bratty Mafuyu.